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One or more keywords matched the following properties of Pincus, David
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overview David Pincus is an Assistant Professor in the Dept. of Molecular Genetics and Cell Biology. The Pincus lab is located in the Center for Physics of Evolving Systems on the 5th floor of GCIS. The Pincus Lab studies cellular adaptation at three levels: cell biological mechanisms of adaptation to environmental stress, global principles of adaptation and resource allocation in complex environments, and the intersection of physiological stress response factors and evolutionary adaptation. David is trained in approaches in biochemistry, biophysics, genetics, genomics, and molecular, cell, computational, systems and synthetic biology. The lab uses budding yeast and cultured human cells as experimental models. Key project areas: 1) Quantitative cell biology of the heat shock response 2) Single-cell transcriptomics in complex stress environments
One or more keywords matched the following items that are connected to Pincus, David
Item TypeName
Concept Amyloid
Concept Adenosine
Concept Antiparkinson Agents
Concept Allosteric Site
Concept Adenosine Monophosphate
Concept Cyclic AMP
Concept Cell Communication
Concept Cerebral Cortex
Concept Computer Simulation
Concept Arginine
Concept Antibodies, Fungal
Concept Base Sequence
Concept Cell Nucleus
Concept Binding Sites
Concept Eukaryotic Cells
Concept Cell Adhesion
Concept Fungal Proteins
Concept Genetic Vectors
Concept Cytosol
Concept Diabetes Mellitus, Type 2
Concept DNA-Binding Proteins
Concept Enzyme Inhibitors
Concept Diglycerides
Concept DNA
Concept Influenza, Human
Concept Introns
Concept Dose-Response Relationship, Drug
Concept Membrane Glycoproteins
Concept Membrane Proteins
Concept Metalloendopeptidases
Concept Models, Molecular
Concept Mice, Inbred CBA
Concept Models, Genetic
Concept Models, Theoretical
Concept Molecular Sequence Data
Concept Mice, Inbred C57BL
Concept Heat-Shock Proteins
Concept RNA, Fungal
Concept Nucleosomes
Concept Nucleotides
Concept Nucleotidyltransferases
Concept Stearoyl-CoA Desaturase
Concept Sulfhydryl Compounds
Concept Plasmids
Concept Protein Conformation
Concept Proteins
Concept Transcription Factors
Concept Repressor Proteins
Concept RNA, Transfer, Lys
Concept Protein Kinases
Concept Regulatory Sequences, Nucleic Acid
Concept RNA, Transfer, Glu
Concept RNA Polymerase II
Concept RNA, Transfer
Concept Cluster Analysis
Concept Time Factors
Concept Triglycerides
Concept Caenorhabditis elegans
Concept Sequence Homology, Amino Acid
Concept Oleic Acid
Concept Protein Structure, Quaternary
Concept Mitogen-Activated Protein Kinases
Concept Meiosis
Concept Alternative Splicing
Concept Protein Structure, Tertiary
Concept Nerve Degeneration
Concept HSP70 Heat-Shock Proteins
Concept Phosphotyrosine
Concept Basic-Leucine Zipper Transcription Factors
Concept Molecular Chaperones
Concept Embryonic Stem Cells
Concept Parkinson Disease
Concept Position-Specific Scoring Matrices
Concept Receptors, G-Protein-Coupled
Concept Chromatin Assembly and Disassembly
Concept Proteasome Endopeptidase Complex
Concept Response Elements
Concept 3' Untranslated Regions
Concept Amino Acid Motifs
Concept Base Pairing
Concept Catalytic Domain
Concept Phosphotransferases
Concept Pheromones
Concept Saccharomyces cerevisiae Proteins
Concept Promoter Regions, Genetic
Concept Receptors, Notch
Concept Recombinant Proteins
Concept Hedgehog Proteins
Concept Ribosomal Proteins
Concept RNA, Transfer, Gln
Concept Saccharomyces cerevisiae
Concept RNA, Messenger
Concept Structure-Activity Relationship
Concept Tunicamycin
Concept Substrate Specificity
Concept HSP40 Heat-Shock Proteins
Concept alpha-Synuclein
Concept Reproducibility of Results
Concept Amyloid beta-Peptides
Concept HSP90 Heat-Shock Proteins
Concept Neurodegenerative Diseases
Concept Caenorhabditis elegans Proteins
Concept GTPase-Activating Proteins
Concept Mutant Proteins
Concept Neural Stem Cells
Concept Transcriptome
Concept Protein Interaction Maps
Concept Induced Pluripotent Stem Cells
Concept Islet Amyloid Polypeptide
Concept Carrier Proteins
Concept Cell Line
Concept Cell Nucleolus
Concept Chromatin
Concept Disease Models, Animal
Concept Kinetics
Concept Models, Biological
Concept Neoplasms
Concept Peptides
Concept Phosphates
Concept Phylogeny
Concept RNA, Ribosomal
Concept Conserved Sequence
Concept Cyclic AMP-Dependent Protein Kinases
Concept Computational Biology
Concept Nucleotide Motifs
Award or Honor Receipt Stewart Trust Cancer Fellowship
Academic Article Hsf1 Phosphorylation Generates Cell-to-Cell Variation in Hsp90 Levels and Promotes Phenotypic Plasticity.
Academic Article Engineering allosteric regulation in protein kinases.
Academic Article Genetic and epigenetic determinants establish a continuum of Hsf1 occupancy and activity across the yeast genome.
Academic Article Hsf1 and Hsp70 constitute a two-component feedback loop that regulates the yeast heat shock response.
Academic Article Dynamic control of Hsf1 during heat shock by a chaperone switch and phosphorylation.
Academic Article BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein response.
Academic Article Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity.
Academic Article Hierarchical Organization Endows the Kinase Domain with Regulatory Plasticity.
Academic Article tRNA thiolation links translation to stress responses in Saccharomyces cerevisiae.
Academic Article Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis.
Academic Article Formation of subnuclear foci is a unique spatial behavior of mating MAPKs during hyperosmotic stress.
Academic Article Specificity in endoplasmic reticulum-stress signaling in yeast entails a step-wise engagement of HAC1 mRNA to clusters of the stress sensor Ire1.
Academic Article Size doesn't matter in the heat shock response.
Academic Article Unrestrained AMPylation targets cytosolic chaperones and activates the heat shock response.
Academic Article Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis.
Academic Article Assigning quantitative function to post-translational modifications reveals multiple sites of phosphorylation that tune yeast pheromone signaling output.
Academic Article Serial Immunoprecipitation of 3xFLAG/V5-tagged Yeast Proteins to Identify Specific Interactions with Chaperone Proteins.
Academic Article Scaffold number in yeast signaling system sets tradeoff between system output and dynamic range.
Academic Article Negative feedback that improves information transmission in yeast signalling.
Academic Article Lipidomic Analysis of a-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.
Academic Article Heat Shock Factor 1 Drives Intergenic Association of Its Target Gene Loci upon Heat Shock.
Academic Article Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness.
Academic Article Messenger RNA targeting to endoplasmic reticulum stress signalling sites.
Academic Article m6A modification of a 3' UTR site reduces RME1 mRNA levels to promote meiosis.
Academic Article Basic leucine zipper transcription factor Hac1 binds DNA in two distinct modes as revealed by microfluidic analyses.
Academic Article Multi-kinase control of environmental stress responsive transcription.
Academic Article The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans.
Academic Article Chaperone AMPylation modulates aggregation and toxicity of neurodegenerative disease-associated polypeptides.
Academic Article Persistent Activation of mRNA Translation by Transient Hsp90 Inhibition.
Academic Article Persistent Activation of mRNA Translation by Transient Hsp90 Inhibition.
Academic Article Subcellular localization of the J-protein Sis1 regulates the heat shock response.
Academic Article Primordial super-enhancers: heat shock-induced chromatin organization in yeast.
Academic Article Inducible transcriptional condensates drive 3D genome reorganization in the heat shock response.
Concept CRISPR-Cas Systems
Concept Protein Aggregation, Pathological
Concept Protein Aggregates
Grant Regulatory Dynamics of the Proteostasis Network
Grant Quantitative approaches to reveal the homeostatic control mechanisms of stress re
Academic Article Transcriptional regulation of Sis1 promotes fitness but not feedback in the heat shock response.
Academic Article Blue light receptor CRY1 regulates HSFA1d nuclear localization to promote plant thermotolerance.
Academic Article Adaptive preservation of orphan ribosomal proteins in chaperone-dispersed condensates.
Academic Article Feedback control of the heat shock response by spatiotemporal regulation of Hsp70.
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